As of 2015, Helion intends to produce and use a combination of deuterium and helium-3 as fuel. This mix allows mostly aneutronic fusion, releasing only 5% of its energy in the form of fast neutrons. The helium-3 is produced by D-D side reactions and is captured and reused, eliminating supply concerns. Helion has a patent on this process.

Helion is sidestepping the neutron damage problem by having only 5% of the energy released as neutrons (from D-D) and those 2.45 MeV neutrons are below the activation energy of many already available materials. Another factor is that their very compact and linear design allows replacement of components within a very short time and for relatively cheap. The expensive components are also relatively far away from the high neutron flux areas of the generator. Again, clever engineering to sidestep and mitigate the problem, rather than a brute force approach to solve it. They will likely breed Tritium (for it to eventually decay into more He3) and with a cylindrical blanket that is a lot easier. But they do not necessarily have to (unlike D-T Tokamaks).